Abstract | INTRODUCTION: METHODS AND RESULTS: In 210 surface and 305 telemetric ECGs recorded in wild-type (C57BL/6; wt; n = 40) and SCP2 null mice (n = 40), no difference was observed at baseline. However, on diet, cycle lengths were prolonged in SCP2 null mice (262.9 +/- 190 vs 146.3 +/- 43 msec), AV conduction was prolonged (58.3 +/- 17 vs 42.6 +/- 4 ms), and QRS complexes were wider (19.1 +/- 5 vs 14.0 +/- 4 ms). In 11 gene-targeted Langendorff-perfused hearts isolated from SCP2 null mice after dietary challenge, complete AV blocks (n = 5/11) or impaired AV conduction (Wenckebach point 132 +/- 27 vs 92 +/- 10 msec; P < 0.05) could be confirmed. Monophasic action potentials were not different between the two genotypes. Left ventricular function studied by echocardiography was similar in both strains. Phytanic acid but not pristanic acid accumulated in the phospholipid fraction of myocardial membranes isolated from SCP2 null mice. CONCLUSION:
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Authors | Gerold Mönnig, Johannes Wiekowski, Paulus Kirchhof, Jörg Stypmann, Gabriele Plenz, Larissa Fabritz, Hans-Jürgen Bruns, Lars Eckardt, Gerd Assmann, Wilhelm Haverkamp, Günter Breithardt, Udo Seedorf |
Journal | Journal of cardiovascular electrophysiology
(J Cardiovasc Electrophysiol)
Vol. 15
Issue 11
Pg. 1310-6
(Nov 2004)
ISSN: 1045-3873 [Print] United States |
PMID | 15574183
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Carrier Proteins
- sterol carrier proteins
- Phytanic Acid
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Topics |
- Animals
- Bradycardia
(metabolism)
- Carrier Proteins
(genetics, metabolism)
- Death, Sudden, Cardiac
- Diet
- Electrocardiography
- Electrophysiologic Techniques, Cardiac
- Female
- Heart Conduction System
(metabolism)
- Male
- Mice
- Mice, Inbred C57BL
- Myocytes, Cardiac
(metabolism)
- Oxidation-Reduction
- Phytanic Acid
(adverse effects, metabolism)
- Time Factors
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