| Abstract | The present study aimed to compare the efficacy for the therapy of GERD of pantoprazole alone with a combination of pantoprazole and mosapride. The study was a prospective, randomized trial involving 68 patients suffering heartburn and/or regurgitation at least twice a week for 6 weeks. Sixty-one patients consented to be randomized to receive either pantoprazole 40 mg b.i.d. (n = 33, group A) or pantoprazole 40 mg b.i.d. plus mosapride 5 mg t.d.s. (n = 28, group B) for 8 weeks. Twenty-four-hour esophageal pH-metry and endoscopy were conducted at recruitment and endoscopy was repeated at 8 weeks in all the patients studied. There were no differences in symptomatic responses to therapy between the groups (69.7% vs 89.2%; P = 0.11). The mean symptom score after 8 weeks was significantly lower in group B (3.78 +/- 3.62 vs 1.67 +/- 2.09; P = 0.009). Nonerosive esophagitis was present in 29 patients. In patients with nonerosive GERD there was no significant difference in symptomatic response to either regimen (17/20 in group A and 7/9 in group B responded; P = 0.63). In erosive esophagitis, symptomatic responses occurred more frequently in group B, 18/19 (94.7%), than in group A, 6/13 (46.2%; P = 0.003). However endoscopic healing of esophagitis occurred equally with either regimen (6/11, 54.5% in group A; 12/17, 70.5% in group B; P = 0.44). In nonerosive GERD, the addition of mosapride offers no benefit over pantoprazole alone. A combination of pantoprazole and mosapride is more effective than pantoprazole alone in providing symptomatic relief to patients with erosive GERD. |
| Authors | K Madan, V Ahuja, P C Kashyap, M P Sharma
(Affiliation: Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.)
|
| Journal | Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus / I.S.D.E
(Dis Esophagus)
Vol. 17
Issue 4
Pg. 274-8
( 2004)
ISSN: 1120-8694 Australia |
| PMID | 15569362
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
| Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Anti-Ulcer Agents
- Benzamides
- Benzimidazoles
- Gastrointestinal Agents
- Morpholines
- Sulfoxides
- pantoprazole
- mosapride
- Omeprazole
|
| Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Ulcer Agents
(therapeutic use)
- Benzamides
(therapeutic use)
- Benzimidazoles
(therapeutic use)
- Chi-Square Distribution
- Double-Blind Method
- Drug Therapy, Combination
- Endoscopy, Gastrointestinal
- Female
- Gastroesophageal Reflux
(classification, drug therapy, physiopathology)
- Gastrointestinal Agents
(therapeutic use)
- Heartburn
(physiopathology)
- Humans
- Hydrogen-Ion Concentration
- Male
- Middle Aged
- Morpholines
(therapeutic use)
- Omeprazole
(analogs & derivatives, therapeutic use)
- Prospective Studies
- Sulfoxides
(therapeutic use)
- Treatment Outcome
|
