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[Protective effect of the intraperitoneal and intragastric administration of PGP-peptide on ethanol-induced erosions and acetate-induced ulcers in rats].

Abstract
We investigated the impact of PGP on ethanol-induced mucosal damages and on the development of acetate gastric ulcers in rats for two ways of introduction--intraperitoneal and intragastric. PGP in the dozes of 0.1, 1 and 10 mg/kg authentically reduced the area of ethanol-induced mucosal damages at intraperitoneal introduction by 43, 70 and 65%, respectively; at intragastric introduction--by 64, 66 and 83%, respectively. Intraperitoneal introduction of PGP in the doze of 1 mg/kg and its intragastric introduction in the doze of 0.1 mg/kg equally reduced the development of acetate gastric ulcers by 73%. Thus, irrespective of the way of its introduction (intraperitoneal or intragastric) and its doze, PGP has a significant protective anti-ulcerous effect and reduces the development of acetate gastric ulcers in rats.
AuthorsZ V Bakaeva, K E Badmaeva, N Ia Zheliaznik, G E Samonina
JournalĖksperimental'nai︠a︡ i klinicheskai︠a︡ gastroėnterologii︠a︡ = Experimental & clinical gastroenterology (Eksp Klin Gastroenterol) Issue 4 Pg. 82-4, 110 ( 2004) ISSN: 1682-8658 [Print] Russia
Vernacular TitleProtektornyĭ éffekt vnutribriushinnogo i vnutrizheludochnogo vvedeniia PGP-peptida na étanolovoe érozirovanie i atsetatnoe iazvoobrazovanie u krys.
PMID15568675 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Oligopeptides
  • Protective Agents
  • prolyl-glycyl-proline
  • Ethanol
  • Proline
  • Acetic Acid
Topics
  • Acetic Acid (toxicity)
  • Administration, Oral
  • Animals
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Ethanol (toxicity)
  • Gastric Mucosa (drug effects)
  • Injections, Intraperitoneal
  • Male
  • Oligopeptides (administration & dosage, therapeutic use)
  • Proline (administration & dosage, analogs & derivatives, therapeutic use)
  • Protective Agents (administration & dosage, therapeutic use)
  • Rats
  • Stomach Ulcer (chemically induced, prevention & control)

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