[Protective effect of the intraperitoneal and intragastric administration of PGP-peptide on ethanol-induced erosions and acetate-induced ulcers in rats].

Abstract

We investigated the impact of PGP on ethanol-induced mucosal damages and on the development of acetate gastric ulcers in rats for two ways of introduction--intraperitoneal and intragastric. PGP in the dozes of 0.1, 1 and 10 mg/kg authentically reduced the area of ethanol-induced mucosal damages at intraperitoneal introduction by 43, 70 and 65%, respectively; at intragastric introduction--by 64, 66 and 83%, respectively. Intraperitoneal introduction of PGP in the doze of 1 mg/kg and its intragastric introduction in the doze of 0.1 mg/kg equally reduced the development of acetate gastric ulcers by 73%. Thus, irrespective of the way of its introduction (intraperitoneal or intragastric) and its doze, PGP has a significant protective anti-ulcerous effect and reduces the development of acetate gastric ulcers in rats.

• Authors: Z V Bakaeva, K E Badmaeva, N Ia Zheliaznik, G E Samonina
• Journal: Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology (Eksp Klin Gastroenterol) Issue 4 Pg. 82-4, 110 ( 2004) ISSN: 1682-8658 [Print] Russia (Federation)
• Vernacular Title: Protektornyĭ éffekt vnutribriushinnogo i vnutrizheludochnogo vvedeniia PGP-peptida na étanolovoe érozirovanie i atsetatnoe iazvoobrazovanie u krys.
• PMID: 15568675 (Publication Type: English Abstract, Journal Article)

Chemical References

• Oligopeptides
• Protective Agents
• prolyl-glycyl-proline
• Ethanol
• Proline
• Acetic Acid

Topics

• Acetic Acid (toxicity)
• Administration, Oral
• Animals
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Ethanol (toxicity)
• Gastric Mucosa (drug effects)
• Injections, Intraperitoneal
• Male
• Oligopeptides (administration & dosage, therapeutic use)
• Proline (administration & dosage, analogs & derivatives, therapeutic use)
• Protective Agents (administration & dosage, therapeutic use)
• Rats
• Stomach Ulcer (chemically induced, prevention & control)