A case of granulocytic sarcoma during complete remission of acute myeloid leukemia with multiple masses involving the larynx and nasopharynx.

Abstract

A thirty-seven-year-old male patient presented with dysphagia and hoarseness six months after complete remission of acute myeloid leukemia (AML-M0), which had been treated with chemotherapy. Physical examination revealed left vocal cord paralysis and involvement of the 9th, 10th, and 12th cranial nerves. Sagittal and axial magnetic resonance scans of the nasopharynx and neck showed a mass in the left retropharyngeal and perivertebral regions, 6x4 cm in size; another mass in the left vallecula, and infiltration of the right preepiglottic tissue by another mass of 2 cm. There was no bone marrow involvement. A diagnosis of granulocytic sarcoma without leukemia relapse was made and the FLAG-Ida regimen was administered, after which partial regression of the masses was observed. However, the patient died due to a pulmonary infection on the 17th day of chemotherapy.

• Authors: Tülay Ozçelik, Ridvan Ali, Fahir Ozkalemkaş, Vildan Ozkocaman, Hakan Coşkun, Levent Erişen, Gülaydan Filiz
• Journal: Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat (Kulak Burun Bogaz Ihtis Derg) Vol. 11 Issue 6 Pg. 183-8 (Dec 2003) ISSN: 1300-7475 [Print] Turkey
• PMID: 15567934 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antineoplastic Agents

Topics

• Adult
• Antineoplastic Agents (therapeutic use)
• Deglutition Disorders (etiology)
• Diagnosis, Differential
• Fatal Outcome
• Hoarseness (etiology)
• Humans
• Laryngeal Neoplasms (complications, diagnosis, diagnostic imaging, pathology)
• Leukemia, Myeloid, Acute
• Magnetic Resonance Imaging
• Male
• Nasopharyngeal Neoplasms (complications, diagnosis, diagnostic imaging, drug therapy, pathology)
• Sarcoma, Myeloid (complications, diagnosis, diagnostic imaging, drug therapy, pathology)
• Tomography, X-Ray Computed