Effects of the plant alkaloid thaliblastine on non-cross-resistant and sensitive human leukemia cells in relation with reversal of acquired anthracycline resistance.

Abstract

Thaliblastine exhibits dose dependent cytotoxic effect on HL-60, HL-60/DOX, RHE and HD-MY-2 leukemia cells. Additionally, typical for apoptosis oligonucleosomal DNA fragmentation could be detected in leukemia cells treated with thaliblastine. Moreover, an MDR-phenotype reversing effect of thaliblastine was also identified.

• Authors: Laszlo E Horvath, Spiro M Konstantinov, Maya V Ilarionova, Dimiter K Todorov
• Journal: Fitoterapia (Fitoterapia) Vol. 75 Issue 7-8 Pg. 712-7 (Dec 2004) ISSN: 0367-326X [Print] Netherlands
• PMID: 15567248 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibiotics, Antineoplastic
• Antineoplastic Agents, Phytogenic
• Plant Extracts
• Doxorubicin

Topics

• Antibiotics, Antineoplastic (pharmacology)
• Antineoplastic Agents, Phytogenic (administration & dosage, chemistry, pharmacology, therapeutic use)
• Apoptosis (drug effects)
• DNA Fragmentation (drug effects)
• Doxorubicin (pharmacology)
• Drug Resistance, Neoplasm
• HL-60 Cells (drug effects)
• Humans
• Phytotherapy
• Plant Extracts (administration & dosage, chemistry, pharmacology, therapeutic use)
• Thalictrum