Soluble fibrin, C-reactive protein, fibrinogen, factor VII, antithrombin, proteins C and S, tissue factor, D-dimer, and prothrombin fragment 1 + 2 in men with acute myocardial infarction </=45 years of age.

Abstract

To evaluate the contribution of hematologic factors and long-term inflammation to the development of myocardial infarction at a young age, we measured hematologic variables, including soluble fibrin and high-sensitivity C-reactive protein, in 90 patients who had myocardial infarction and 138 controls </=45 years of age. Plasma levels of soluble fibrin and C-reactive protein were significantly higher in patients than in controls. On multivariate regression analysis, soluble fibrin was the strongest predictor of myocardial infarction at a young age.

• Authors: Masahiko Saigo, David D Waters, Satoshi Abe, Sadatoshi Biro, Shinichi Minagoe, Ikuro Maruyama, Chuwa Tei
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 94 Issue 11 Pg. 1410-3 (Dec 01 2004) ISSN: 0002-9149 [Print] United States
• PMID: 15566913 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Fibrin

Topics

• Adult
• Age Factors
• Biomarkers (blood)
• Fibrin (analysis)
• Humans
• Inflammation
• Male
• Middle Aged
• Multivariate Analysis
• Myocardial Infarction (pathology)
• Predictive Value of Tests