Abstract | BACKGROUND: METHODS: RESULTS: Rats treated with volatile anesthetics had lower plasma creatinine and reduced renal necrosis 24-72 h after injury compared with rats anesthetized with pentobarbital or ketamine. Twenty-four hours after injury, sevoflurane-, isoflurane-, or halothane-treated rats had creatinine (+/- SD) of 2.3 +/- 0.7 mg/dl (n = 12), 1.8 +/- 0.5 mg/dl (n = 6), and 2.4 +/- 1.2 mg/dl (n = 6), respectively, compared with rats treated with pentobarbital (5.8 +/- 1.2 mg/dl, n = 9) or ketamine (4.6 +/- 1.2 mg/dl, n = 8). Among the volatile anesthetics, desflurane demonstrated the least reduction in plasma creatinine after 24 h (4.1 +/- 0.8 mg/dl, n = 12). Renal cortices from volatile anesthetic-treated rats demonstrated reduced expression of intercellular adhesion molecule 1 protein and messenger RNA as well as messenger RNAs encoding proinflammatory cytokines and chemokines. Volatile anesthetic treatment reduced renal cortex myeloperoxidase activity and reduced nuclear translocation of proinflammatory nuclear factor kappaB. Adenosine triphosphate-dependent potassium channels are not involved in sevoflurane-mediated renal protection because glibenclamide did not block renal protection ( creatinine: 2.4 +/- 0.4 mg/dl, n = 3). CONCLUSION:
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Authors | H Thomas Lee, Ayuko Ota-Setlik, Yulei Fu, Samih H Nasr, Charles W Emala |
Journal | Anesthesiology
(Anesthesiology)
Vol. 101
Issue 6
Pg. 1313-24
(Dec 2004)
ISSN: 0003-3022 [Print] United States |
PMID | 15564938
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- ATP-Binding Cassette Transporters
- Anesthetics, Inhalation
- Cytokines
- Inflammation Mediators
- KATP Channels
- NF-kappa B
- Potassium Channels
- Potassium Channels, Inwardly Rectifying
- Proteins
- Tumor Necrosis Factor-alpha
- uK-ATP-1 potassium channel
- Intercellular Adhesion Molecule-1
- Creatinine
- Peroxidase
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Topics |
- ATP-Binding Cassette Transporters
- Anesthetics, Inhalation
(therapeutic use)
- Animals
- Creatinine
(blood)
- Cytokines
(biosynthesis, genetics)
- Electrophoretic Mobility Shift Assay
- Immunoblotting
- Inflammation
(pathology)
- Inflammation Mediators
(metabolism)
- Intercellular Adhesion Molecule-1
(metabolism)
- Ischemia
(prevention & control)
- KATP Channels
- Kidney
(pathology)
- Kidney Cortex
(enzymology)
- Kidney Diseases
(pathology, prevention & control)
- Kidney Function Tests
- Male
- NF-kappa B
(metabolism)
- Necrosis
- Peroxidase
(metabolism)
- Potassium Channels
(agonists)
- Potassium Channels, Inwardly Rectifying
- Proteins
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Renal Circulation
(physiology)
- Reperfusion Injury
(prevention & control)
- Reverse Transcriptase Polymerase Chain Reaction
- Tumor Necrosis Factor-alpha
(metabolism)
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