Abstract | OBJECTIVE: DATA SOURCES: STUDY SELECTION AND DATA EXTRACTION: Data were obtained primarily from randomized placebo-controlled trials upon which key recommendations are based. DATA SYNTHESIS:
Antibiotics are often prescribed for months or even years for treatment of chronic inflammatory conditions such as acne, blepharitis, cardiovascular disease, cystic fibrosis, periodontitis, rosacea, and rheumatoid arthritis. Randomized controlled trials have shown that azithromycin is useful in the management of cystic fibrosis and the tetracyclines are beneficial in the management of rheumatoid arthritis, acne, blepharitis, and periodontitis. Several large, randomized controlled trials have failed to show any benefit of macrolides in the secondary prevention of cardiovascular disease. No randomized placebo-controlled clinical trials have been performed to assess the efficacy of macrolides or tetracyclines in patients with rosacea. CONCLUSIONS:
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Authors | Stacy A Voils, Martin E Evans, Matthew T Lane, Robert H Schosser, Robert P Rapp |
Journal | The Annals of pharmacotherapy
(Ann Pharmacother)
Vol. 39
Issue 1
Pg. 86-94
(Jan 2005)
ISSN: 1060-0280 [Print] United States |
PMID | 15562139
(Publication Type: Journal Article, Review)
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Chemical References |
- Anti-Bacterial Agents
- Macrolides
- Tetracyclines
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Topics |
- Acne Vulgaris
(drug therapy)
- Anti-Bacterial Agents
(therapeutic use)
- Arthritis, Rheumatoid
(drug therapy)
- Blepharitis
(drug therapy)
- Cardiovascular Diseases
(drug therapy)
- Chronic Disease
- Cystic Fibrosis
(drug therapy)
- Humans
- Inflammation
(drug therapy)
- Macrolides
(therapeutic use)
- Periodontitis
(drug therapy)
- Rosacea
(drug therapy)
- Tetracyclines
(therapeutic use)
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