The macrophage-activating lipopeptide-2 accelerates wound healing in diabetic mice.

Abstract

Wound healing in healthy individuals proceeds at an optimal rate. However, in patients, with -- e.g.-- locally impaired blood flow or diabetes, chronic wounds develop and often become infected. Chronic wounds mean a low quality of life for the afflicted patients, not to mention enormous costs. Rather than using recombinant growth factors to accelerate wound healing, we employed the toll-like receptor agonist macrophage-activating lipopeptide-2 (MALP-2) to improve the healing of full-thickness excision skin wounds in an animal model with obese, diabetic mice. A gene array experiment suggested that MALP-2 stimulates the release of various mediators involved in wound healing. Further data to be presented in this study will show (i) that MALP-2 is capable of stimulating the appearance of the monocyte chemoattractant protein-1 at the wound site, (ii) that this leads to increased leucocyte and, in particular, macrophage infiltration and (iii) that MALP-2-treated wounds closed 2 weeks earlier than vehicle-treated controls. MALP-2, thus, appears to stimulate the early inflammatory process needed to set in motion the ensuing consecutive natural steps of wound healing resulting in wound closure.

• Authors: U Deiters, J Barsig, B Tawil, P F Mühlradt
• Journal: Experimental dermatology (Exp Dermatol) Vol. 13 Issue 12 Pg. 731-9 (Dec 2004) ISSN: 0906-6705 [Print] Denmark
• PMID: 15560756 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hyaluronan Receptors
• Lipopeptides
• Oligopeptides
• Platelet Endothelial Cell Adhesion Molecule-1
• macrophage stimulatory lipopeptide 2
• Hydroxyproline

Topics

• Animals
• Dendritic Cells (metabolism)
• Diabetes Mellitus, Experimental (metabolism, pathology)
• Gene Expression Regulation
• Humans
• Hyaluronan Receptors (biosynthesis)
• Hydroxyproline (chemistry)
• Leukocytes (metabolism)
• Lipopeptides
• Macrophage Activation
• Macrophages (metabolism)
• Mice
• Mice, Inbred C57BL
• Oligonucleotide Array Sequence Analysis
• Oligopeptides (metabolism, physiology)
• Platelet Endothelial Cell Adhesion Molecule-1 (biosynthesis)
• Skin (pathology)
• Time Factors
• Wound Healing