HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Effects of tautomycin, a protein phosphatase inhibitor, on recycling of mammalian cell surface molecules.

Abstract
The effects of tautomycin, a protein phosphatase inhibitor, on recycling of cell surface molecules were studied with transferrin receptor (TFR) of human myeloid leukemia K562 cells and with CD4 of murine thymocytes. Tautomycin increased expression of TFR of K562 cells whereas phorbol dibutylate (PDBu) decreased it. Tautomycin inhibited PDBu-induced down-regulation of CD4 although it did not induce up-regulation. Okadaic acid also inhibited down-regulation of CD4 which was induced by PDBu. The results suggest that certain inhibitors of protein phosphatases preferentially inhibit endocytosis of cell surface molecules.
AuthorsT Kurisaki, J Magae, K Isono, K Nagai, M Yamasaki
JournalThe Journal of antibiotics (J Antibiot (Tokyo)) Vol. 45 Issue 2 Pg. 252-7 (Feb 1992) ISSN: 0021-8820 [Print] JAPAN
PMID1556018 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Alkaloids
  • Antifungal Agents
  • Antigens, CD4
  • Carbazoles
  • Ethers, Cyclic
  • Indole Alkaloids
  • Pyrans
  • Receptors, Transferrin
  • Spiro Compounds
  • tautomycin
  • Okadaic Acid
  • Phorbol 12,13-Dibutyrate
  • dinophysistoxin 1
  • staurosporine aglycone
  • Protein Kinase C
  • Staurosporine
Topics
  • Alkaloids (pharmacology)
  • Antifungal Agents (pharmacology)
  • Antigens, CD4 (metabolism)
  • Carbazoles
  • Down-Regulation (drug effects)
  • Ethers, Cyclic (pharmacology)
  • Indole Alkaloids
  • Okadaic Acid
  • Phorbol 12,13-Dibutyrate (pharmacology)
  • Protein Kinase C (antagonists & inhibitors)
  • Pyrans (pharmacology)
  • Receptors, Transferrin (metabolism)
  • Spiro Compounds
  • Staurosporine

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: