[Morphological changes in prostatic tissue of patients with benign prostatic hyperplasia treated with permixon].

Abstract

A pilot trial has been performed to assess effects of permixon on prostatic tissue in patients with benign prostatic hyperplasia (BPH). A total of 49 BPH and control patients entered the trial. 36 patients of the study group were randomized into 3 subgroups of 12 patients each. Permixon was taken in a standard dose of 320 mg/day for 3, 6 and 12 months, respectively. Mean duration of BPH was 3.7 years (0-8 years). Mean value of PCA was 6.0 ng/ml. The control group of 13 patients were not given permixon. Multifocal prostatic biopsy was performed in all the patients before and after the treatment or follow-up. Stromal-parenchymatous correlation in the study group significantly increased (by 59%)--from 3.28 (0.25-9.61) to 5.22 (1.20-10.67) (p = 0.0002). For the control group this correlation was insignificant. Permixon-treated patients demonstrated inhibition of prostatic epithelium proliferative activity by 32% (p = 0.0001) and a rise in the stage of proliferative centers development from stage II-III to IV-V. Intensity of inflammation in prostatic tissue decreased by 53% in the study group and insignificantly in the control group. Thus, permixon treatment of BPH leads to a significant rise in stromal-parenchymatous correlation due to inhibition of proliferative activity of prostatic epithelium and attenuation of inflammation.

• Authors: A V Sivkov, Iu V Kudriavtsev, A A Medvedev, S V Razumov, S A Kochetov
• Journal: Urologiia (Moscow, Russia : 1999) (Urologiia) 2004 Sep-Oct Issue 5 Pg. 10-6 ISSN: 1728-2985 [Print] Russia (Federation)
• Vernacular Title: Morfologicheskie izmeneniia v tkani predstatel'noĭ zhelezy bol'nykh s dobrokachestvennoĭ giperplazieĭ predstatel'noĭ zhelezy pri lechenii permiksonom.
• PMID: 15560155 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Androgen Antagonists
• Plant Extracts
• saw palmetto extract

Topics

• Aged
• Androgen Antagonists (therapeutic use)
• Cell Proliferation (drug effects)
• Epithelium (drug effects, pathology)
• Humans
• Male
• Middle Aged
• Plant Extracts (therapeutic use)
• Prostate (drug effects, pathology)
• Prostatic Hyperplasia (drug therapy, pathology)
• Serenoa