Oral vaccination with recombinant Yersinia enterocolitica expressing hybrid type III proteins protects gerbils from amebic liver abscess.

Abstract

Protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess by oral immunization with live attenuated Yersinia enterocolitica expressing the Entamoeba histolytica galactose-inhibitable lectin that has been fused to the Yersinia outer protein E (YopE). Protection was dependent on the presence of the YopE translocation domain but was independent from the antibody response to the ameba lectin.

• Authors: Hannelore Lotter, Holger Rüssmann, Jürgen Heesemann, Egbert Tannich
• Journal: Infection and immunity (Infect Immun) Vol. 72 Issue 12 Pg. 7318-21 (Dec 2004) ISSN: 0019-9567 [Print] United States
• PMID: 15557659 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Bacterial Outer Membrane Proteins
• Lectins
• Recombinant Fusion Proteins
• Vaccines, Synthetic
• yopE protein, Yersinia

Topics

• Administration, Oral
• Animals
• Bacterial Outer Membrane Proteins (immunology)
• Entamoeba histolytica (immunology)
• Gerbillinae
• Humans
• Lectins (immunology)
• Liver Abscess, Amebic (prevention & control)
• Recombinant Fusion Proteins (immunology)
• Vaccination
• Vaccines, Synthetic (immunology)
• Yersinia enterocolitica (genetics)