| Abstract | Protection against invasive amebiasis was achieved in the gerbil model for amebic liver abscess by oral immunization with live attenuated Yersinia enterocolitica expressing the Entamoeba histolytica galactose-inhibitable lectin that has been fused to the Yersinia outer protein E (YopE). Protection was dependent on the presence of the YopE translocation domain but was independent from the antibody response to the ameba lectin. |
| Authors | Hannelore Lotter, Holger Rüssmann, Jürgen Heesemann, Egbert Tannich
(Affiliation: Bernhard Nocht Institute for Tropical Medicine, Bernhard Nocht Strasse 74, 20359 Hamburg, Germany.)
|
| Journal | Infection and immunity
(Infect Immun)
Vol. 72
Issue 12
Pg. 7318-21
(Dec 2004)
ISSN: 0019-9567 United States |
| PMID | 15557659
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Bacterial Outer Membrane Proteins
- Lectins
- Recombinant Fusion Proteins
- Vaccines, Synthetic
- yopE protein, Yersinia
|
| Topics |
- Administration, Oral
- Animals
- Bacterial Outer Membrane Proteins
(immunology)
- Entamoeba histolytica
(immunology)
- Gerbillinae
- Humans
- Lectins
(immunology)
- Liver Abscess, Amebic
(prevention & control)
- Recombinant Fusion Proteins
(immunology)
- Vaccination
- Vaccines, Synthetic
(immunology)
- Yersinia enterocolitica
(genetics)
|
