Expression of a beta-defensin mRNA, lingual antimicrobial peptide, in bovine mammary epithelial tissue is induced by mastitis.

Abstract

The expression of a beta-defensin, the lingual antimicrobial peptide (LAP), in response to mastitis was investigated by real-time PCR of RNA from mastitic and control udder quarters. There was a positive relationship between somatic cell count in milk and LAP expression. In situ hybridization showed that LAP mRNA was expressed in epithelial cells of mastitic tissue. These results suggest that LAP plays a role in the innate immune response to mastitis.

• Authors: Kara Swanson, Stas Gorodetsky, Laura Good, Stephen Davis, David Musgrave, Kerst Stelwagen, Vicki Farr, Adrian Molenaar
• Journal: Infection and immunity (Infect Immun) Vol. 72 Issue 12 Pg. 7311-4 (Dec 2004) ISSN: 0019-9567 [Print] United States
• PMID: 15557657 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• RNA, Messenger
• beta-Defensins

Topics

• Animals
• Cattle
• Cell Count
• Female
• Mammary Glands, Animal (metabolism)
• Mastitis, Bovine (metabolism, pathology)
• RNA, Messenger (analysis)
• beta-Defensins (genetics)