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Urinary excretion of lignans after administration of isolated plant lignans to rats: the effect of single dose and ten-day exposures.

Abstract
The difference in urinary excretion of mammalian and plant lignans in rats was determined after oral administration of equivalent doses (25 mg/kg of body weight) of 7-hydroxymatairesinol (HMR), lariciresinol (LAR), matairesinol (MR), and secoisolariciresinol (SECO). Twenty-four hours-urine samples were collected after a single dose and after administration of one dose/day for 10 days. Eight lignans were analysed in urine extracts using a high-performance liquid chromatography-tandem mass spectrometry method showing good sensitivity and repeatability. After a single dose of HMR, LAR, MR, and SECO, the main metabolites were 7-hydroxyenterolactone (HENL), cyclolariciresinol (CLAR), enterolactone (ENL), and enterodiol (END), respectively, but after 10-day exposure ENL was the main metabolite of all the tested lignans, showing a considerably higher excretion than after a single dose. Metabolic transformations of plant lignans into each other could also be observed.
AuthorsAnnika I Smeds, Niina M Saarinen, Teija T Hurmerinta, Pauliina E Penttinen, Rainer E Sjöholm, Sari I Mäkelä
JournalJournal of chromatography. B, Analytical technologies in the biomedical and life sciences (J Chromatogr B Analyt Technol Biomed Life Sci) Vol. 813 Issue 1-2 Pg. 303-12 (Dec 25 2004) ISSN: 1570-0232 [Print] Netherlands
PMID15556546 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Lignans
Topics
  • Animals
  • Lignans (administration & dosage, urine)
  • Male
  • Plants (chemistry)
  • Rats
  • Rats, Sprague-Dawley

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