| Abstract | Current treatments of non-small-cell lung cancer (NSCLC) are inadequate and new therapies are being developed that target specific cellular signaling proteins associated with tumor growth. One potential target is protein kinase C (PKC)-alpha, a signaling molecule with an important role in cell regulation and proliferation. The present study examines the expression levels of PKC-alpha in NSCLC to better understand the distribution of PKC-alpha in NSCLC. We analyzed tumor specimens from an independent tumor tissue bank to determine PKC-alpha protein and messenger RNA gene expression in NSCLC. In addition, we used publicly available gene expression array data to further understand PKC-a-associated gene expression profiles in NSCLC. We found that PKC-alpha is highly expressed in < or = 20% of patients with NSCLC. We also found that PKC-alpha was preferentially expressed in adenocarcinoma compared with squamous cell carcinoma of the lung. |
| Authors | Michael Lahn, Chen Su, Shuyu Li, Marcio Chedid, Kimberly R Hanna, Jeremy R Graff, George E Sandusky, Doreen Ma, Clet Niyikiza, Karen L Sundell, William J John, Thomas J Giordano, David G Beer, Blake M Paterson, Eric Wen Su, Thomas F Bumol
(Affiliation: Oncology Product Development, Eli Lilly and Company, Indianapolis, IN 46285, USA. mlahn at lilly.com)
|
| Journal | Clinical lung cancer
(Clin Lung Cancer)
Vol. 6
Issue 3
Pg. 184-9
(Nov 2004)
ISSN: 1525-7304 United States |
| PMID | 15555220
(Publication Type: Journal Article)
|
| Chemical References |
- RNA, Messenger
- PRKCA protein, human
- Protein Kinase C-alpha
- Protein Kinase C
|
| Topics |
- Carcinoma, Non-Small-Cell Lung
(genetics, pathology)
- Gene Expression Profiling
- Humans
- Lung Neoplasms
(genetics, pathology)
- Oligonucleotide Array Sequence Analysis
- Protein Kinase C
(genetics)
- Protein Kinase C-alpha
- RNA, Messenger
(metabolism)
|
