Abstract | INTRODUCTION: MATERIAL AND METHODS: RESULTS: All patients except one (patient number five) showed positive patch-test reactions to at least two different drugs. Nine patients (64.3%) were cross-sensitized to three or more different drugs, and 57.1% of patients were sensitized to four or more sympathomimetic drugs. Patients who experienced generalized rashes caused by orally administered pseudoephedrine had a stronger response and more cross-reactivity with other sympathomimetic drugs in patch tests than those who experienced local contact dermatitis. CONCLUSIONS: We conclude that there is cross-reactivity among the different sympathomimetic drugs tested, especially if the drug is administered systemically.
|
Authors | Ruth Barranco, Angel Rodríguez, Manuel de Barrio, Mā J Trujillo, Consolación de Frutos, Víctor Matheu, Pilar Tornero, Teresa Herrero |
Journal | American journal of clinical dermatology
(Am J Clin Dermatol)
Vol. 5
Issue 5
Pg. 351-5
( 2004)
ISSN: 1175-0561 [Print] New Zealand |
PMID | 15554736
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
|
Chemical References |
- Allergens
- Ethanolamines
- Mydriatics
- Sympathomimetics
- Phenylephrine
- Phenylpropanolamine
- fepradinol
- Oxymetazoline
- Ephedrine
- Methoxamine
- Dimethyl Sulfoxide
|
Topics |
- Adult
- Aged
- Aged, 80 and over
- Allergens
(adverse effects, immunology)
- Conjunctivitis, Allergic
(immunology)
- Cross Reactions
- Dermatitis, Allergic Contact
(immunology)
- Dimethyl Sulfoxide
- Ephedrine
(immunology)
- Ethanolamines
(immunology)
- Female
- Humans
- Male
- Methoxamine
(immunology)
- Middle Aged
- Mydriatics
(adverse effects, immunology)
- Oxymetazoline
(immunology)
- Patch Tests
(methods)
- Phenylephrine
(immunology)
- Phenylpropanolamine
(immunology)
- Single-Blind Method
- Sympathomimetics
(adverse effects, immunology)
- Time Factors
|