[Induction and reversibility of thyroid proliferative changes in suckling rats given thiocyanate].

Abstract

Potassium thiocyanate given in the drinking water of pregnant rats led to decreased body weight in their 14-day-old offspring (27%) without altering thyroid weight. Reduction of the suckling rat's body weight could be explained be defective thyroxinemia (38). Plasma FT3 and TSH were unchanged after thiocyanate treatment. The biochemical changes were in agreement with the histological aspects of the hypothyroid animals. The typical pattern was hyperplastic goiter. Colloid volume was reduced compared with controls. Presence of resorbed peripheral vacuoles, a sign of thyroid hyperactivity, was disclosed by a three-fold increase in radioiodide (131I) uptake compared with controls. When the antithyroid drug was removed from the mother's milk, the pups'weight increased but did not reach control values. Plasma thyroid hormone levels returned to normal and even exceeded control values in spite of partial recovery of thyroid iodine content when thiocyanate treatment was stopped for ten days.

• Authors: L Soussia, F Ben Hamida, F Guermazi, N Zeghal
• Journal: Annales d'endocrinologie (Ann Endocrinol (Paris)) Vol. 65 Issue 5 Pg. 451-8 (Oct 2004) ISSN: 0003-4266 [Print] France
• Vernacular Title: Induction et réversibilité d'action du thiocyanate sur la fonction thyroïdienne chez le rat en période d'allaitement.
• PMID: 15550887 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antithyroid Agents
• Thiocyanates
• Thyrotropin
• Iodine
• Thyroxine
• potassium thiocyanate

Topics

• Animals
• Animals, Suckling
• Antithyroid Agents (administration & dosage)
• Body Weight
• Female
• Gestational Age
• Goiter (chemically induced, pathology)
• Hypothyroidism (blood, chemically induced, pathology)
• Iodine (analysis)
• Maternal-Fetal Exchange
• Pregnancy
• Rats
• Thiocyanates (administration & dosage)
• Thyroid Gland (chemistry, pathology)
• Thyrotropin (blood)
• Thyroxine (blood)