Expression of cdc25A and cdc25B phosphatase in breast carcinoma.

Abstract

BACKGROUND:

Previous studies have indicated that cdc25B and cdc25A phosphatase stimulate cell cycle progression and also play a role in malignant transformation of cells. In this study, we investigated the expression of these phosphatases in breast carcinoma to elucidate their significance.

METHODS:

We immunohistochemically examined cdc25B and cdc25A expression in 46 cases of breast carcinoma.

RESULTS:

Cdc25B and cdc25A were negative or only equivocally expressed in glandular epithelial cells. In breast carcinoma, 56.5% of cases had high levels of cdc25B expression. Interestingly, the expression of cdc25B was significantly lower in cases with biologically aggressive phenotypes. The cdc25A level was high in 69.6% of cases, but we could not find any relationship between cdc25A expression and clinicopathological parameters.

CONCLUSION:

These results suggest that cdc25B is important especially in the early phase of breast carcinoma progression.

• Authors: Yasuhiro Ito, Hiroshi Yoshida, Takashi Uruno, Yuuki Takamura, Akihiro Miya, Kanji Kuma, Akira Miyauchi
• Journal: Breast cancer (Tokyo, Japan) (Breast Cancer) Vol. 11 Issue 3 Pg. 295-300 ( 2004) ISSN: 1340-6868 [Print] Japan
• PMID: 15550849 (Publication Type: Journal Article)

Chemical References

• Cell Cycle Proteins
• CDC25A protein, human
• CDC25B protein, human
• cdc25 Phosphatases

Topics

• Adult
• Breast Neoplasms (metabolism, pathology)
• Cell Cycle Proteins (analysis)
• Female
• Humans
• Immunohistochemistry
• Middle Aged
• Neoplasm Staging
• cdc25 Phosphatases (analysis)