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A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population.

Abstract
To investigate whether a C to G transversion at position 77 in exon A of the CD45 gene is associated with the development of diabetes mellitus type 1 (T1D), we studied 165 patients and 220 control individuals. The frequency of the 77G allele in the control group was 1.1%, which was not significantly different from the 1.2% found in the patient group (P = 0.922). The C to G transversion does not seem to be associated with susceptibility for T1D.
AuthorsH Thude, S Rosenhahn, W Hunger-Dathe, U-A Müller, D Barz
JournalEuropean journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics (Eur J Immunogenet) Vol. 31 Issue 6 Pg. 245-7 (Dec 2004) ISSN: 0960-7420 [Print] England
PMID15548260 (Publication Type: Journal Article)
Chemical References
  • Antigens, CD45
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
Topics
  • Antigens, CD45 (genetics, immunology)
  • Diabetes Mellitus, Type 1 (genetics, immunology)
  • Exons
  • Genetic Predisposition to Disease
  • Genotype
  • Germany
  • Humans
  • Point Mutation
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Sequence Analysis, DNA

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