A transmembrane protein-tyrosine phosphatase receptor type C (CD45) exon A point mutation (77 C to G) is not associated with the development of type 1 diabetes mellitus in a German population.

To investigate whether a C to G transversion at position 77 in exon A of the CD45 gene is associated with the development of diabetes mellitus type 1 (T1D), we studied 165 patients and 220 control individuals. The frequency of the 77G allele in the control group was 1.1%, which was not significantly different from the 1.2% found in the patient group (P = 0.922). The C to G transversion does not seem to be associated with susceptibility for T1D.
AuthorsH Thude, S Rosenhahn, W Hunger-Dathe, U-A Müller, D Barz
JournalEuropean journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics (Eur J Immunogenet) Vol. 31 Issue 6 Pg. 245-7 (Dec 2004) ISSN: 0960-7420 [Print] England
PMID15548260 (Publication Type: Journal Article)
Chemical References
  • Antigens, CD45
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Antigens, CD45 (genetics, immunology)
  • Diabetes Mellitus, Type 1 (genetics, immunology)
  • Exons
  • Genetic Predisposition to Disease
  • Genotype
  • Germany
  • Humans
  • Point Mutation
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Sequence Analysis, DNA

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: