IgM-enriched immunoglobulin (pentaglobin) positively influences the course of post-surgical intra-abdominal infections.

Abstract

BACKGROUND:

Polyvalent IgM-enriched intravenous human immunoglobulin (IVIG) preparations are discussed to be beneficial regarding sepsis outcome.

MATERIALS AND METHODS:

Sixty-four patients with abdominal infection were treated with Pentaglobin or Albumin. Serum levels of endotoxin and chemokines were determined.

RESULTS:

Incidence of fever was 19/28 in the pentaglobin and 18/26 in the albumin group, the percentage of days with fever was 34 +/- 26 for pentaglobin and 43 +/- 25 for albumin (mean +/-SD). Procalcitonin levels of the pentaglobin treated patients fell under the upper limit of normal on day six whereas levels of albumin patients remained elevated.

CONCLUSION:

Pentaglobin has a positive influence on the course of post-surgery intra-abdominal infection.

• Authors: H B Reith, S K Rauchschwalbe, U Mittelkötter, R Engemann, A Thiede, A Arnold, R Lissner
• Journal: European journal of medical research (Eur J Med Res) Vol. 9 Issue 10 Pg. 479-84 (Oct 29 2004) ISSN: 0949-2321 [Print] England
• PMID: 15546815 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Albumins
• CALCA protein, human
• Immunoglobulin A
• Immunoglobulin M
• Interleukin-8
• Protein Precursors
• Tumor Necrosis Factor-alpha
• Calcitonin
• pentaglobulin
• Calcitonin Gene-Related Peptide

Topics

• APACHE
• Abdomen (surgery)
• Adult
• Aged
• Albumins (therapeutic use)
• Bacterial Infections (drug therapy)
• Calcitonin (blood)
• Calcitonin Gene-Related Peptide
• Female
• Humans
• Immunoglobulin A (therapeutic use)
• Immunoglobulin M (therapeutic use)
• Interleukin-8 (physiology)
• Length of Stay
• Male
• Middle Aged
• Postoperative Complications (drug therapy)
• Protein Precursors (blood)
• Tumor Necrosis Factor-alpha (physiology)