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Successful desensitization to enfuvirtide after a hypersensitivity reaction in an HIV-1-infected man.

Abstract
We report a case of successful, rapid desensitization to enfuvirtide after a hypersensitivity reaction in a man with highly drug-resistant human immunodeficiency virus type 1 infection. The patient was desensitized in a monitored intensive care unit and tolerated the rapid desensitization protocol without any serious adverse effects. This case illustrates the ability to safely desensitize patients with limited treatment options who require enfuvirtide therapy.
AuthorsJoseph A DeSimone, Ambrish Ojha, Rolee Pathak, John Cohn
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America (Clin Infect Dis) Vol. 39 Issue 10 Pg. e110-2 (Nov 15 2004) ISSN: 1537-6591 [Electronic] United States
PMID15546072 (Publication Type: Case Reports, Journal Article)
Chemical References
  • HIV Envelope Protein gp41
  • HIV Fusion Inhibitors
  • Peptide Fragments
  • Enfuvirtide
Topics
  • Adult
  • Drug Hypersensitivity (therapy)
  • Enfuvirtide
  • HIV Envelope Protein gp41 (adverse effects, immunology, therapeutic use)
  • HIV Fusion Inhibitors (adverse effects, immunology, therapeutic use)
  • HIV Infections (drug therapy)
  • HIV-1
  • Humans
  • Male
  • Peptide Fragments (adverse effects, immunology, therapeutic use)
  • Remission Induction

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