Abstract | OBJECTIVE: To study the effect of laser treatment on rosacea, a common facial skin disease with symptoms of blushing, redness, telangiectasis, papules, pustules, and diffuse swelling of the skin, we focused on the stinging sensation and performed immunohistochemical evaluation of nerve density and neuropeptide expression. DESIGN: Clinical investigation as well as the lactic acid (stinger) test was performed before and 3 months after the treatment with flashlamp pulsed dye laser, when skin biopsy specimens were also taken. SETTING: University hospital. PATIENTS: MAIN OUTCOME MEASURES: RESULTS: CONCLUSIONS:
Laser treatment of rosacea that destroys small vessels has a good medical relevance because it reduces the unpleasant symptoms of the sensitive skin. A neurogenic etiology of stinging may be possible.
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Authors | Solbritt Lonne-Rahm, Klas Nordlind, Desiree Wiegleb Edström, Anne-Marie Ros, Mats Berg |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 140
Issue 11
Pg. 1345-9
(Nov 2004)
ISSN: 0003-987X [Print] United States |
PMID | 15545543
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- UCHL1 protein, human
- Substance P
- Lactic Acid
- Vasoactive Intestinal Peptide
- Ubiquitin Thiolesterase
- Calcitonin Gene-Related Peptide
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Topics |
- Adult
- Aged
- Calcitonin Gene-Related Peptide
(metabolism)
- Dermis
(metabolism)
- Epidermis
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Lactic Acid
- Laser Therapy
- Lip
- Male
- Middle Aged
- Nose
- Rosacea
(diagnosis, metabolism, radiotherapy)
- Substance P
(metabolism)
- Ubiquitin Thiolesterase
(metabolism)
- Vasoactive Intestinal Peptide
(metabolism)
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