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Metronidazole for the prevention of dry socket after removal of partially impacted mandibular third molar: a randomised controlled trial.

AbstractWe randomised 119 patients who had been referred for removal of partially impacted mandibular third molars to be given either metronidazole 1600 mg or placebo as a single dose 45 min before operation. Ten of the fifty-nine patients who were given metronidazole and 13 of the 60 given placebo developed dry sockets. Two variables were significantly associated with the development of a dry socket: pericoronitis and oral contraceptives.
AuthorsM Bergdahl, L Hedström (Affiliation: Department of Odontology, Faculty of Medicine and Odontology, Umeå University, Umeå, Sweden.)
JournalThe British journal of oral & maxillofacial surgery (Br J Oral Maxillofac Surg) Vol. 42 Issue 6 Pg. 555-8 (Dec 2004) ISSN: 0266-4356 Scotland
PMID15544888 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Anti-Infective Agents
  • Contraceptives, Oral
  • Metronidazole
Topics
  • Administration, Oral
  • Adolescent
  • Adult
  • Anti-Infective Agents (administration & dosage)
  • Chi-Square Distribution
  • Contraceptives, Oral (adverse effects)
  • Double-Blind Method
  • Dry Socket (etiology, prevention & control)
  • Female
  • Humans
  • Logistic Models
  • Male
  • Mandible
  • Metronidazole (administration & dosage)
  • Molar, Third (surgery)
  • Pericoronitis (complications)
  • Preoperative Care
  • Statistics, Nonparametric
  • Tooth Extraction (adverse effects)
  • Tooth, Impacted (complications, surgery)