Abstract | OBJECTIVE: In 2003, critical care and infectious disease experts representing 11 international organizations developed management guidelines for recombinant human activated protein C that would be of practical use for the bedside clinician, under the auspices of the Surviving Sepsis Campaign, an international effort to increase awareness and improve outcome in severe sepsis. DESIGN: The process included a modified Delphi method, a consensus conference, several subsequent smaller meetings of subgroups and key individuals, teleconferences, and electronic-based discussion among subgroups and among the entire committee. METHODS: The modified Delphi methodology used for grading recommendations built on a 2001 publication sponsored by the International Sepsis Forum. We undertook a systematic review of the literature graded along five levels to create recommendation grades from A to E, with A being the highest grade. Pediatric considerations to contrast adult and pediatric management are in the article by Parker et al. on p. S591. CONCLUSION:
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Authors | François Fourrier |
Journal | Critical care medicine
(Crit Care Med)
Vol. 32
Issue 11 Suppl
Pg. S534-41
(Nov 2004)
ISSN: 0090-3493 [Print] United States |
PMID | 15542961
(Publication Type: Journal Article, Review, Systematic Review)
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Chemical References |
- Protein C
- Recombinant Proteins
- Heparin
|
Topics |
- Consensus Development Conferences as Topic
- Contraindications
- Disseminated Intravascular Coagulation
(drug therapy)
- Evidence-Based Medicine
- Heparin
(administration & dosage)
- Humans
- Practice Guidelines as Topic
- Protein C
(therapeutic use)
- Recombinant Proteins
(adverse effects, therapeutic use)
- Sepsis
(drug therapy)
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