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Efficacy of oral treatment with BV-araU against cutaneous infection with herpes simplex type 1 in shaved mice.

Abstract
The effect of oral BV-araU was tested in cutaneous model infections of shaved Balb/c mice with herpes simplex virus type 1 (HSV-1). Progression of cutaneous symptoms associated with cutaneous infection with HSV-1 F strain was inhibited by BV-araU at doses of 20 and 50 mg/kg twice daily, beginning one day post-infection, resulting in significant increase in the survival rate. Onset of disease was suppressed in most animals receiving 100 mg of BV-araU per kg. BV-araU (20 mg/kg or more) also significantly increased the survival rate of mice infected with HSV-1 WT-51 strain. The efficacy of BV-araU was not affected by gender or age (6-9 weeks) of the mice. BV-araU was effective even when the treatment was started 2.5 days post-infection. The efficacy of BV-araU against F strain infection was comparable to that of acyclovir, but acyclovir showed therapeutic effects at lower doses compared with BV-araU against WT-51 strain infection. Against infection of cyclophosphamide-treated immunosuppressed mice with HSV-1 KOS(S) strain, BV-araU decreased the morbidity rate and severity of symptoms at doses of 200 and 100 mg/kg, respectively, and all mice given 50 mg of BV-araU or more per kg survived, suggesting oral efficacy can be achieved against HSV-1 infections in immunosuppressed individuals.
AuthorsH Machida, K Ijichi, J Takezawa
JournalAntiviral research (Antiviral Res) Vol. 17 Issue 2 Pg. 133-43 (Feb 1992) ISSN: 0166-3542 [Print] NETHERLANDS
PMID1554238 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Antiviral Agents
  • Arabinofuranosyluracil
  • sorivudine
  • Acyclovir
Topics
  • Acyclovir (therapeutic use)
  • Administration, Oral
  • Animals
  • Antiviral Agents (administration & dosage, therapeutic use)
  • Arabinofuranosyluracil (administration & dosage, analogs & derivatives, therapeutic use)
  • Disease Models, Animal
  • Drug Administration Schedule
  • Drug Evaluation, Preclinical
  • Female
  • Herpes Simplex (drug therapy)
  • Immune Tolerance
  • Male
  • Mice
  • Mice, Inbred BALB C

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