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Biased immunoglobulin G (IgG) subclass production in a case of hyper-IgM syndrome.

Abstract
Hyper-immunoglobulin M (IgM) syndrome (HIGM) is a rare heterogeneous primary immune deficiency. We describe a patient with HIGM characterized by skewed production of serum IgG subclasses and normal somatic hypermutation. This case may represent a subgroup of HIGM type 4 that is characterized by a biased switching to the V-region proximal constant regions.
AuthorsG R McLean, K K Miller, J W Schrader, A K Junker
JournalClinical and diagnostic laboratory immunology (Clin Diagn Lab Immunol) Vol. 11 Issue 6 Pg. 1192-3 (Nov 2004) ISSN: 1071-412X [Print] United States
PMID15539528 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Immunoglobulin Constant Regions
  • Immunoglobulin G
  • Immunoglobulin M
  • Immunoglobulin Variable Region
  • Immunoglobulin mu-Chains
Topics
  • Adolescent
  • Female
  • Gene Rearrangement, B-Lymphocyte (genetics)
  • Humans
  • Hypergammaglobulinemia (blood, genetics, pathology)
  • Immunoglobulin Constant Regions (genetics)
  • Immunoglobulin G (blood)
  • Immunoglobulin M (blood, genetics)
  • Immunoglobulin Variable Region (genetics)
  • Immunoglobulin mu-Chains (genetics)

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