SPECT imaging of serotonin transporter binding in patients with generalized anxiety disorder.

Abstract	The purpose of this study was to characterize the binding properties of serotonin transporter (5-HTT) in the brain of the patients with generalized anxiety disorder (GAD) in comparison to healthy subjects using single photon emission computer tomography (SPECT) with the radioligand [123I]nor-beta-CIT. The subjects were 7 patients with GAD and 7 matched healthy volunteers. The regions of interest (ROI) were the midbrain and the thalamus. The comparison of the volumes of distribution did not show significant differences between the patients and controls in the binding of nor-beta-CIT to 5-HTT in the ROI. Binding of 5-HTT in the midbrain of patients was significantly and negatively correlated with their anxiety levels measured by the visual analogue scale immediately before the first scan (r=-0.79, p=0.035). This study failed to demonstrate an altered functional activity of 5-HTT in patients with GAD when compared with controls.
Authors	Eduard Maron, Jyrki T Kuikka, Kai Ulst, Jari Tiihonen, Veiko Vasar, Jakov Shlik
Journal	European archives of psychiatry and clinical neuroscience (Eur Arch Psychiatry Clin Neurosci) Vol. 254 Issue 6 Pg. 392-6 (Dec 2004) ISSN: 0940-1334 [Print] Germany
PMID	15538601 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Iodine Radioisotopes Membrane Glycoproteins Membrane Transport Proteins Nerve Tissue Proteins SLC6A4 protein, human Serotonin Plasma Membrane Transport Proteins Serotonin Cocaine
Topics	Adult Analysis of Variance Anxiety Disorders (diagnostic imaging, metabolism) Case-Control Studies Cocaine (analogs & derivatives, pharmacokinetics) Female Humans Iodine Radioisotopes (pharmacokinetics) Male Membrane Glycoproteins (metabolism) Membrane Transport Proteins (metabolism) Mesencephalon (diagnostic imaging, metabolism) Middle Aged Nerve Tissue Proteins (metabolism) Serotonin (metabolism) Serotonin Plasma Membrane Transport Proteins Thalamus (diagnostic imaging, metabolism) Time Factors Tomography, Emission-Computed, Single-Photon

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