Abstract | PURPOSE: MATERIALS AND METHODS: RESULTS:
Phytoestrogens (50 to 100 microM) and bicalutamide (10 to 50 microM) alone decreased the cell number in all 3 cell lines. Phytoestrogens (50 microM) combined with bicalutamide (10 microM) further decreased the number of RWPE-1 and PC-3 cells compared to these agents alone. Tectorigenin and irigenin inhibited the proliferation of RWPE-1, LNCaP and PC-3 cells, causing G1 arrest and the induction of p21WAF1 or p27 protein expression, whereas bicalutamide induced apoptosis in a dose dependent manner in all 3 cell lines. Phytoestrogens did not have antiandrogenic activity. CONCLUSIONS:
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Authors | Colm Morrissey, Jasmin Bektic, Barbara Spengler, David Galvin, Volker Christoffel, Helmut Klocker, John M Fitzpatrick, R William G Watson |
Journal | The Journal of urology
(J Urol)
Vol. 172
Issue 6 Pt 1
Pg. 2426-33
(Dec 2004)
ISSN: 0022-5347 [Print] United States |
PMID | 15538285
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoflavones
- Phytoestrogens
- Plant Extracts
- irigenin
- tectorigenin
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Topics |
- Cell Division
(drug effects)
- Cell Line, Tumor
- Drug Evaluation, Preclinical
- Humans
- Iridaceae
- Isoflavones
(pharmacology, therapeutic use)
- Male
- Phytoestrogens
(pharmacology, therapeutic use)
- Plant Extracts
(pharmacology, therapeutic use)
- Prostatic Neoplasms
(drug therapy, pathology)
- Tumor Cells, Cultured
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