Abstract | INTRODUCTION: METHODS: We evaluated this genetic polymorphism in association with breast cancer risk using data from the Shanghai Breast Cancer Study, a population-based case-control study conducted in urban Shanghai from 1996 to 1998. The MnSOD Val-9Ala polymorphism was examined in 1125 breast cancer cases and 1197 age-frequency-matched control individual. RESULTS:
Breast cancer risk was slightly elevated in women with Ala/Ala genotype (odds ratio [OR] 1.3, 95% confidence interval [CI] 0.7-2.3), particularly among premenopausal women (OR 1.8, 95% CI 0.9-3.7), as compared with those with Val/Val genotype. The increased risk with the Ala/Ala genotype was stronger among premenopausal women with a higher body mass index (OR 2.5, 95% CI 0.9-7.0) and more years of menstruation (OR 2.6, 95% CI 0.8-8.0). The risk among premenopausal women was further increased twofold to threefold among those with a low intake of fruits, vegetables, vitamin supplements, selenium, or antioxidant vitamins, including carotenes and vitamins A, C, and E. However, the frequency of the Ala allele was low (14%) in the study population, and most of the ORs provided above were not statistically significant. CONCLUSION: The present study provides some evidence that genetic polymorphism in the MnSOD gene may be associated with increased risk of breast cancer among Chinese women with high levels of oxidative stress or low intake of antioxidants. Studies with a larger sample size are needed to confirm the findings.
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Authors | Qiuyin Cai, Xiao-Ou Shu, Wanqing Wen, Jia-Rong Cheng, Qi Dai, Yu-Tang Gao, Wei Zheng |
Journal | Breast cancer research : BCR
(Breast Cancer Res)
Vol. 6
Issue 6
Pg. R647-55
( 2004)
ISSN: 1465-542X [Electronic] England |
PMID | 15535847
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antioxidants
- Superoxide Dismutase
- Valine
- Alanine
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Topics |
- Adult
- Alanine
(genetics)
- Alleles
- Antioxidants
(administration & dosage)
- Breast Neoplasms
(enzymology, etiology, genetics)
- Case-Control Studies
- Cocarcinogenesis
- Diet
- Female
- Genetic Predisposition to Disease
- Humans
- Middle Aged
- Oxidative Stress
(genetics)
- Polymorphism, Genetic
- Postmenopause
- Premenopause
- Superoxide Dismutase
(genetics)
- Valine
(genetics)
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