Abstract |
Treatment response and side effects of venlafaxine were evaluated in an open-label trial of elderly outpatients with dysthymic disorder (DD). Patients received flexible dose (up to 300 mg/d) venlafaxine ( Effexor XR) for 12 weeks. Of 23 study patients, 18 completed the trial. Fourteen (60.9%) were responders in intent-to-treat analyses with the last observation carried forward, and 77.8% were responders in completer analyses. Nearly half the sample (47.8%) met criteria for remission. In the intent-to-treat sample, increased severity of depression at baseline was associated with superior response, and the presence of cardiovascular disease was associated with poorer response. Venlafaxine open-label treatment was associated with fairly high response rates and generally good tolerability in elderly patients with DD. These results indicate that in elderly patients with DD, placebo-controlled trials of a dual reuptake inhibitor such as venlafaxine would be needed to assess its efficacy or to compare its efficacy to that of other antidepressants.
|
Authors | D P Devanand, Nicole Juszczak, Mitchell S Nobler, Nancy Turret, Linda Fitzsimons, Harold A Sackeim, Steven P Roose |
Journal | Journal of geriatric psychiatry and neurology
(J Geriatr Psychiatry Neurol)
Vol. 17
Issue 4
Pg. 219-24
(Dec 2004)
ISSN: 0891-9887 [Print] United States |
PMID | 15533993
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Cyclohexanols
- Serotonin Uptake Inhibitors
- Venlafaxine Hydrochloride
|
Topics |
- Aged
- Cyclohexanols
(administration & dosage, therapeutic use)
- Diagnostic and Statistical Manual of Mental Disorders
- Drug Administration Schedule
- Dysthymic Disorder
(diagnosis, drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Selective Serotonin Reuptake Inhibitors
(administration & dosage, therapeutic use)
- Venlafaxine Hydrochloride
|