Abstract | AIMS/HYPOTHESIS: METHOD: Thirteen overweight subjects with type 2 DM were examined. The subjects who were fed 20 kcal/kg body weight were divided into two subgroups according to whether they were treated by buformin ( Buformin group), or dietary therapy alone (Diet group). Six patients were in Buformin group and seven patients were in Diet group. We calculated insulin-mediated glucose uptake by the liver and peripheral tissues using euglycemic hyperinsulinemic clamp combined with an oral glucose load before and after buformin treatment or diet therapy for 2 weeks. RESULTS: Fasting plasma glucose, total cholesterol (T-chol), LDL-cholesterol ( LDL-chol), and sTNFR2 were significantly decreased, and hepatic glucose uptake significantly increased from 32 +/- 7 to 42 +/- 7% (P < 0.05) in Buformin group but did not changed significantly in Diet group. However, the glucose infusion rate thought to express insulin sensitivity in peripheral tissue, TNF-alpha, sTNFR1, fasting plasma insulin, C-peptide, and NEFA levels did not change significantly in both the groups after treatment. CONCLUSION/INTERPRETATION:
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Authors | S Ohara, R Komatsu, T Matsuyama |
Journal | Diabetes research and clinical practice
(Diabetes Res Clin Pract)
Vol. 66
Issue 2
Pg. 133-8
(Nov 2004)
ISSN: 0168-8227 [Print] Ireland |
PMID | 15533580
(Publication Type: Journal Article)
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Chemical References |
- Cholesterol, LDL
- Lipids
- Receptors, Tumor Necrosis Factor
- Receptors, Tumor Necrosis Factor, Type II
- Cholesterol
- Glucose
- Buformin
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Topics |
- Buformin
(pharmacology)
- Cholesterol
(blood)
- Cholesterol, LDL
(blood)
- Diabetes Mellitus, Type 2
(blood, physiopathology)
- Female
- Glucose
(metabolism)
- Humans
- Insulin Resistance
- Lipids
(blood)
- Liver
(metabolism, physiopathology)
- Male
- Middle Aged
- Obesity
(blood, physiopathology)
- Receptors, Tumor Necrosis Factor
(blood)
- Receptors, Tumor Necrosis Factor, Type II
(blood)
|