Abstract |
The reduced antigen content diphtheria, tetanus and pertussis ( dTpa) vaccine (Boostrixtrade mark) has been shown to induce a strong booster response to all the vaccine components in 4-6 year olds. However, anti- diphtheria antibody levels were observed to be lower when compared to the "full strength" paediatric DTPa vaccine. To assess the impact of this difference on long-term protection, a mathematical model was developed to predict diphtheria antibody decay over time. The model was based on a linear decrease in log-transformed antibody concentrations after the first year post-vaccination. When applied to data collected 3.5 years after vaccination of 4-6 year olds with either DTPa or dTpa, the model predicted that 10 years post-vaccination, 98.6% of subjects vaccinated with dTpa were likely to remain seroprotected against diphtheria, compared to 99.6% vaccinated with DTPa. Therefore, the difference observed in diphtheria antibody geometric mean concentrations 1 month after booster vaccination at 4-6 years with dTpa or DTPa is unlikely to be of clinical relevance 10 years later at the time of the adolescent booster.
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Authors | Brigitte Cheuvart, Margaret Burgess, Fred Zepp, Jussi Mertsola, Joanne Wolter, Lode Schuerman |
Journal | Vaccine
(Vaccine)
Vol. 23
Issue 3
Pg. 336-42
(Dec 02 2004)
ISSN: 0264-410X [Print] Netherlands |
PMID | 15530678
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Antibodies, Bacterial
- Diphtheria-Tetanus-Pertussis Vaccine
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Topics |
- Adult
- Antibodies, Bacterial
(blood)
- Child
- Child, Preschool
- Cohort Studies
- Diphtheria
(immunology)
- Diphtheria-Tetanus-Pertussis Vaccine
(immunology)
- Humans
- Immunization Schedule
- Immunization, Secondary
- Models, Biological
- Randomized Controlled Trials as Topic
- Time Factors
- Vaccination
(methods)
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