Abstract | OBJECTIVE: DESIGN: Randomized, double-blind, controlled trial. SETTING: Pediatric intensive care unit of a referral and teaching hospital. SUBJECTS: INTERVENTION: Patients received either fluconazole (n = 22) or itraconazole (n = 21), about 10 mg/kg orally or through a gastric tube, and were monitored for clinical and mycological cure (sterile fungal blood culture), blood counts, and liver and renal functions. MEASUREMENTS AND MAIN RESULTS: The clinical characteristics of two groups were comparable. The cure rate was similar in both the groups: itraconazole 17 of 21 (81%) and fluconazole 18 of 22 (82%). Crude mortality rate ( itraconazole 9.5% and fluconazole 13.6%) was also comparable in two groups of patients. The frequency of electrolyte disturbance was very low and similar in both the groups. Blood urea, creatinine, liver enzymes, and serum bilirubin were not adversely affected. CONCLUSIONS:
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Authors | Rakesh K Mondal, Sunit C Singhi, Arunaloke Chakrabarti, Jayashree M |
Journal | Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
(Pediatr Crit Care Med)
Vol. 5
Issue 6
Pg. 561-5
(Nov 2004)
ISSN: 1529-7535 [Print] United States |
PMID | 15530193
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antifungal Agents
- Itraconazole
- Fluconazole
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Topics |
- Antifungal Agents
(therapeutic use)
- Candidiasis
(drug therapy, mortality)
- Child
- Child, Preschool
- Cross Infection
(drug therapy)
- Double-Blind Method
- Female
- Fluconazole
(therapeutic use)
- Fungemia
(drug therapy, mortality)
- Humans
- Infant
- Intensive Care Units, Pediatric
- Itraconazole
(therapeutic use)
- Male
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