HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

New treatment option for heart failure patients: eplerenone.

Abstract
Aldosterone plays an important role in the harmful cardiac remodeling process and pathophysiology of heart failure after a myocardial infarction. Until recently, spironolactone (Aldactone) was the only pharmacologic agent available to directly block the deleterious effects of aldosterone. The use of spironolactone is complicated by its antiprogesterone and antiandrogen side effects, such as gynecomastia and menstrual irregularities. Eplerenone (Inspra), a member of a new class of drugs called selective aldosterone receptor antagonists, was recently approved for the treatment of both hypertension and post-myocardial infarction heart failure and appears to be devoid of the antiprogesterone and antiandrogen effects. In a trial in patients with heart failure following a myocardial infarction, eplerenone treatment significantly reduced mortality and morbidity compared to placebo. Eplerenone may be considered as part of the therapeutic plan in patients who have suffered a myocardial infarction and demonstrate evidence of heart failure.
AuthorsMary Ross Southworth, Larisa H Cavallari
JournalThe Journal of cardiovascular nursing (J Cardiovasc Nurs) 2004 Nov-Dec Vol. 19 Issue 6 Pg. 390-5 ISSN: 0889-4655 [Print] United States
PMID15529060 (Publication Type: Journal Article, Review)
Chemical References
  • Mineralocorticoid Receptor Antagonists
  • Spironolactone
  • Aldosterone
  • Eplerenone
Topics
  • Aldosterone (physiology)
  • Drug Monitoring (methods)
  • Eplerenone
  • Heart Failure (drug therapy, etiology, metabolism, physiopathology)
  • Humans
  • Mineralocorticoid Receptor Antagonists (pharmacology, therapeutic use)
  • Myocardial Infarction (complications)
  • Patient Selection
  • Renin-Angiotensin System (drug effects, physiology)
  • Spironolactone (adverse effects, analogs & derivatives, pharmacology, therapeutic use)
  • Treatment Outcome
  • Ventricular Remodeling (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: