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Parent phenotype and age dependence, on rat glioma tumor rejection.

AbstractBACKGROUND: The brain, despite the blood-brain barrier, does not escape to the highly variable host rejection response mediated by a very strong and complex immune reaction when rat glioma cells are transplanted into the adult animal. METHODS: Crosses were performed among parents that are able or enable to reject a well-known brain tumor cell line (C6). Newborn animals were also challenged with rat glioma cells both in the brain and the side flanks. RESULTS: The percentage of susceptibility or resistance to develop a lethal glioma can be estimated knowing the parental phenotypes. When both parents had rejected an induced tumor, 63% of the progeny will also reject it. Similarly, if both parents died as a consequence of the tumor, 70% of the progeny would also be unable to reject the challenge of glioma C6 cells. Newborn animals do not have a mature immune system and they tolerate transplanted cells much better than adults. We found no rejection to glioma C6, at both brain and side flank sites, in 1-day-old neonatal Wistar rats. Tumors were beginning to be eliminated if the cells are inoculated at day 3 from birth on the flanks, and at 1 week from birth on the brain. CONCLUSIONS: There is a genetic component conferring susceptibility or resistance to the lethal effect of tumor development and progression depending on the parental phenotype of the adult rats. Neonatal rats represent a much more reliable model than adults to study experimental therapies against gliomas.
AuthorsAlicia Gonzalez-Martin, Daniel Muñoz-Espin, Andrés M Alonso, Marta Izquierdo (Affiliation: Departamento de Biologia Molecular-Centro de Biologia Molecular Severo Ochoa, Spain.)
JournalJournal of neuro-oncology (J Neurooncol) Vol. 70 Issue 1 Pg. 29-34 (Oct 2004) ISSN: 0167-594X [Print] Netherlands
PMID15527104 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Topics
  • Age Factors
  • Animals
  • Animals, Newborn
  • Brain Neoplasms (immunology, pathology)
  • Cells, Cultured
  • Crosses, Genetic
  • Female
  • Genes, MHC Class I (physiology)
  • Glioma (immunology, pathology)
  • Graft Rejection (genetics)
  • Immune Tolerance
  • Magnetic Resonance Imaging
  • Male
  • Neoplasm Transplantation
  • Phenotype
  • Pregnancy
  • Rats
  • Rats, Wistar
  • T-Lymphocytes (immunology, pathology)

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