From Kretschmer's trials binding personality traits with risk of
psychoses have been described in literature. Still there is lack of one theory linking genetic factors with
schizophrenia. In 1962 Meehl, introducing the term "
schizotaxia", had been trying to find an answer to such a question. He described
schizotaxia as subtle neuronal integration deficit caused by a single genetic factor, which depending on conditions, can give schizotypy or
schizophrenia. Actually, this theory has only historical meaning. Recently Tsuang and Faraone reformulated the concept of
schizotaxia used in clinical studies. Preliminary results lead to a conclusion that presence of
schizotaxia has a detrimental influence on social functioning, which is improving after
neuroleptic therapy. Studies confirmed that the risk of
schizophrenia in persons with
schizotaxia was higher as compared to persons without such characteristics. It is supposed, that paying attention to traits of
schizotaxia will improve the possibility of early diagnosis of
schizophrenia.