Production by Escherichia coli isolates of siderophore and other virulence factors and their pathogenic role in a cutaneous infection model.

Abstract

Escherichia coli isolates from urinary tract infections (UTIs) (n = 124), extra-urinary sites (n = 37) and normal faecal samples (n = 51) were examined for the presence of virulence factors, including siderophores (aerobactin and enterobactin). The proportion of aerobactin producers was significantly higher in UTI (69.4%; p 0.001) and extra-urinary samples (70.3%; p 0.007) than in controls (41.2%), while the proportion of enterobactin producers was significantly lower in the UTI samples than in the controls (p 0.027). In a cutaneous infection model, aerobactin-positive E. coli showed more growth than non-aerobactin and non-enterobactin isolates, even when other virulence factors were identical.

• Authors: M Demir, I Kaleli
• Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases (Clin Microbiol Infect) Vol. 10 Issue 11 Pg. 1011-4 (Nov 2004) ISSN: 1198-743X [Print] England
• PMID: 15522006 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Hydroxamic Acids
• Siderophores
• Virulence Factors
• aerobactin
• Enterobactin

Topics

• Animals
• Enterobactin (metabolism)
• Escherichia coli (growth & development, pathogenicity)
• Humans
• Hydroxamic Acids (metabolism)
• Mice
• Mice, Inbred BALB C
• Siderophores (biosynthesis)
• Skin Diseases, Bacterial (microbiology, physiopathology)
• Urinary Tract Infections (microbiology, physiopathology)
• Virulence Factors (biosynthesis)