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Predicting cisplatin ototoxicity in children: the influence of age and the cumulative dose.

Abstract
The aim of this study was to determine the risk factors for high-frequency hearing loss in children treated with cisplatin. We scored off-treatment pure-tone audiograms from 153 children (age 6 months to 18 years) who had completed cisplatin therapy (40-200 mg/m(2)/cycle) for germ cell tumours, hepatoblastoma, neuroblastoma or osteosarcoma. The risk of developing bilateral moderate to severe high-frequency hearing loss was significantly related to the age at treatment (P<0.001), and individual and cumulative cisplatin dosages (both P<0.005). Logistic regression showed that children younger than 5 years were at a greater risk of sustaining cisplatin ototoxicity than children older than 15 years, controlling for individual and cumulative doses of cisplatin (Odds Ratio (OR)=21.17, 95% Confidence Interval (CI): 2.48-180.94). Age at treatment and the cumulative dose of cisplatin were the two most important risk factors in predicting moderate to severe high-frequency hearing loss in children treated with cisplatin.
AuthorsY Li, R B Womer, J H Silber
JournalEuropean journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 40 Issue 16 Pg. 2445-51 (Nov 2004) ISSN: 0959-8049 [Print] England
PMID15519518 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Antineoplastic Agents
  • Cisplatin
Topics
  • Adolescent
  • Age Factors
  • Antineoplastic Agents (adverse effects)
  • Audiometry, Pure-Tone
  • Child
  • Child, Preschool
  • Cisplatin (adverse effects)
  • Confidence Intervals
  • Dose-Response Relationship, Drug
  • Female
  • Hearing Loss, High-Frequency (chemically induced)
  • Humans
  • Infant
  • Logistic Models
  • Male
  • Predictive Value of Tests
  • Risk Assessment
  • Risk Factors

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