| Abstract | Leprosy patients undergoing phase II trials in two hospitals of New Delhi, India, were HLA typed to see the association of HLA with differential responsiveness to Mycobacterium w vaccine. The vaccine comprises an atypical, nonpathogenic mycobacterium, Mycobacterium w, which has cross-reactive antigens with M. leprae. Multibacillary patients who are lepromin negative are vaccinated at an interval of 3 months. Considerable improvement is evident in the patients in terms of a decline in bacterial indices and histopathological and immunological upgrading. But all the patients do not respond to the vaccine in the same manner; some are slow responders, while others are good responders. HLA-A28 and DQw3 (DQw8 + 9) were found to be associated with slow responsiveness, while DQw1 and DQw7 were found to be associated with a more rapid responsiveness to the M. w vaccine. However, these associations were not significant after P correction for the number of antigens tested for each locus except for HLA-DQw3 (DQw8 and DQw9) and DQw7. DQw7, a new defined split of HLA-DQw3, seems to be associated with the responsiveness to M. w vaccine. |
| Authors | R Rani, S A Zaheer, N R Suresh, R Walia, S K Parida, A Mukherjee, R Mukherjee, G P Talwar
(Affiliation: Microbiology Laboratory, National Institute of Immunology, New Delhi, India.)
|
| Journal | Journal of clinical immunology
(J Clin Immunol)
Vol. 12
Issue 1
Pg. 50-5
(Jan 1992)
ISSN: 0271-9142 UNITED STATES |
| PMID | 1551942
(Publication Type: Journal Article)
|
| Chemical References |
- HLA Antigens
- HLA-A Antigens
- HLA-B Antigens
- HLA-DQ Antigens
- HLA-DR Antigens
- Vaccines, Inactivated
- Lepromin
|
| Topics |
- Cross Reactions
- HLA Antigens
(analysis, immunology)
- HLA-A Antigens
(analysis)
- HLA-B Antigens
(analysis)
- HLA-DQ Antigens
(analysis)
- HLA-DR Antigens
(analysis)
- Humans
- Immunophenotyping
- Lepromin
- Leprosy
(drug therapy, immunology, pathology)
- Mycobacterium
(immunology)
- Vaccines, Inactivated
(immunology)
|
