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Expression of ephrin-A ligands and EphA receptors in the developing mouse tooth and its supporting tissues.

Abstract
Ephrins are cell-membrane-bound ligands for Eph receptor tyrosine kinases and regulate a variety of developmental processes. In order to investigate the potential roles of the ephrin-Eph system in tooth formation, we studied the cellular mRNA expression of Ephrin-A1-A5 and EphA2, EphA3, EphA4, EphA7, and EphA8 receptors during embryonic histomorphogenesis of the mouse first molar (embryonic days 11.5-18.5). Ephrin-A1, ephrin-A5, EphA2, EphA3, EphA4, and EphA7 were expressed in the tooth germ at the epithelial thickening stage, and later, ephrin-A1, ephrin-A5, EphA2, EphA4, and EphA7 showed distinct expression patterns in the enamel organ undergoing epithelial folding morphogenesis. Prior to birth, ephrin-A1, ephrin-A5, EphA2, and EphA4 transcripts were present in the cuspal area of the dental papilla including the preodontoblasts. In addition, ephrin-A1 and ephrin-A5 were seen in the forming blood vessels and alveolar bone, respectively. In contrast, ephrin-A2, ephrin-A3, and ephrin-A4 showed ubiquitous expression during odontogenesis, whereas EphA8 transcripts were not observed. During dental trigeminal axon pathfinding (embryonic days 12.5-13.5), ephrin-A2, ephrin-A4, and ephrin-A5 were evenly distributed in the trigeminal ganglion, whereas EphA7 was expressed in a subset of ganglion cells. These results suggest regulatory roles for ephrin-A/EphA signaling in the formation of the tooth organ proper and its supporting tissues.
AuthorsKeijo Luukko, Sigbjørn Løes, Inger Hals Kvinnsland, Päivi Kettunen
JournalCell and tissue research (Cell Tissue Res) Vol. 319 Issue 1 Pg. 143-52 (Jan 2005) ISSN: 0302-766X [Print] Germany
PMID15517401 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Ephrins
  • Ligands
  • RNA, Messenger
  • Receptors, Eph Family
Topics
  • Animals
  • Dental Enamel (cytology, embryology, metabolism)
  • Ephrins (biosynthesis, genetics)
  • Gene Expression Regulation, Developmental
  • In Situ Hybridization
  • Ligands
  • Mandible (embryology)
  • Mice
  • Molar (cytology, embryology, metabolism)
  • Odontoblasts (cytology, metabolism)
  • Odontogenesis
  • RNA, Messenger (biosynthesis)
  • Receptors, Eph Family (biosynthesis, genetics)
  • Trigeminal Ganglion (cytology, embryology, metabolism)

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