A synthetic retinoid Am80 (tamibarotene) rescues the memory deficit caused by scopolamine in a passive avoidance paradigm.

Abstract

Memory deficit in rats treated with scopolamine was rescued by several synthetic retinoids, RAR-ligands (Am80, Am555S, Tp80) and an RXR-ligand (HX630). These results may have implications for the treatment of Alzheimer's disease, age-related dementia, Parkinson's disease, and other neurological disorders.

• Authors: Koichi Shudo, Hiroyuki Kagechika, Noriyuki Yamazaki, Masaharu Igarashi, Chiaki Tateda
• Journal: Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 27 Issue 11 Pg. 1887-9 (Nov 2004) ISSN: 0918-6158 [Print] Japan
• PMID: 15516744 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antibodies, Monoclonal
• Benzazepines
• Benzoates
• HX 630
• Nootropic Agents
• Platelet Glycoprotein GPIIb-IIIa Complex
• Retinoids
• TAC 101
• Tetrahydronaphthalenes
• Trimethylsilyl Compounds
• tamibarotene
• Scopolamine

Topics

• Animals
• Antibodies, Monoclonal (administration & dosage, therapeutic use)
• Avoidance Learning (drug effects)
• Benzazepines (administration & dosage, therapeutic use)
• Benzoates (administration & dosage, therapeutic use)
• Dose-Response Relationship, Drug
• Male
• Memory Disorders (chemically induced, drug therapy, psychology)
• Nootropic Agents (administration & dosage, therapeutic use)
• Platelet Glycoprotein GPIIb-IIIa Complex (immunology)
• Rats
• Rats, Wistar
• Retinoids (administration & dosage, therapeutic use)
• Scopolamine
• Tetrahydronaphthalenes (administration & dosage, therapeutic use)
• Time Factors
• Trimethylsilyl Compounds (administration & dosage, therapeutic use)