Abstract | PURPOSE: In this retrospective study, we analyzed the relevance of human leukocyte antigen (HLA) expression to clinical behavior of uveal melanoma and correlated it with conventional light microscopic parameters. METHODS: RESULTS: In-group A (n = 35) tumors with no extrascleral extension and no liver metastases HLA class I antigen and beta 2 microglobulin are negative (absent staining) in 30 choroidal melanomas. In-group B (n = 4) they are weak (heterogeneous) in 3 tumors. In-group C (n = 6) all the 6 tumors have a positive (bright staining) immunoexpression. No statistical significance was obtained when HLA and beta 2 microglobulin immunoreactivity was compared against largest tumor diameter (LTD), tumor infiltrating lymphocytes (TIL), mitosis and nuclear grade. The difference of HLA class I and beta 2-microglobulin imunoreactivity among the various cell types spindle, mixed and epithelioid was statistically significant (p = 0.003), (p = 0.004). The difference in immunoreactivity between tumors with no liver metastases and tumors with liver metastases was statistically significant (p < 0.001). CONCLUSIONS:
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Authors | Subramanian Krishnakumar, Dhiraj Abhyankar, Sundaram Amirtha Lakshmi, Vaijayanthi Pushparaj, Mahesh Palanivelu Shanmugam, Jyotirmay Biswas |
Journal | Current eye research
(Curr Eye Res)
Vol. 28
Issue 6
Pg. 409-16
(Jun 2004)
ISSN: 0271-3683 [Print] England |
PMID | 15512948
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Histocompatibility Antigens Class I
- beta 2-Microglobulin
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Topics |
- Adolescent
- Adult
- Aged
- Antibodies, Monoclonal
- Choroid Neoplasms
(metabolism, pathology)
- Eye Neoplasms
(metabolism, secondary)
- Female
- Histocompatibility Antigens Class I
(metabolism)
- Humans
- Immunoenzyme Techniques
- Liver Neoplasms
(metabolism, secondary)
- Lymphocytes, Tumor-Infiltrating
(pathology)
- Male
- Melanoma
(metabolism, secondary)
- Middle Aged
- Retrospective Studies
- Scleral Diseases
(metabolism, pathology)
- beta 2-Microglobulin
(metabolism)
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