Abstract |
In a study of chromosome fragility carried out under folate and thymidine deficiency conditions, we observed a seven- to ninefold increase of the incidence of premature centromere divisions (PCDs) affecting all chromosomes. This early separation of centromeres is clearly a culture effect and distinct from PCD and centromere splitting (CS), which imply a defect in the centromere of one or more chromosomes.
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Authors | C Fuster, R Miró, L Barrios, J Egozcue |
Journal | Cancer genetics and cytogenetics
(Cancer Genet Cytogenet)
Vol. 58
Issue 2
Pg. 152-4
(Feb 1992)
ISSN: 0165-4608 [Print] United States |
PMID | 1551079
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Cells, Cultured
- Centromere
(drug effects, ultrastructure)
- Chromosome Banding
- Chromosome Fragile Sites
- Chromosome Fragility
- Humans
- Karyotyping
- Methotrexate
(pharmacology)
- Reference Values
- Thymidine
(metabolism)
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