HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Induction of premature centromere division affecting all chromosomes under culture conditions of fragile site expression.

Abstract
In a study of chromosome fragility carried out under folate and thymidine deficiency conditions, we observed a seven- to ninefold increase of the incidence of premature centromere divisions (PCDs) affecting all chromosomes. This early separation of centromeres is clearly a culture effect and distinct from PCD and centromere splitting (CS), which imply a defect in the centromere of one or more chromosomes.
AuthorsC Fuster, R Miró, L Barrios, J Egozcue
JournalCancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 58 Issue 2 Pg. 152-4 (Feb 1992) ISSN: 0165-4608 [Print] United States
PMID1551079 (Publication Type: Journal Article)
Chemical References
  • Thymidine
  • Methotrexate
Topics
  • Cells, Cultured
  • Centromere (drug effects, ultrastructure)
  • Chromosome Banding
  • Chromosome Fragile Sites
  • Chromosome Fragility
  • Humans
  • Karyotyping
  • Methotrexate (pharmacology)
  • Reference Values
  • Thymidine (metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: