Abstract |
ADVANTAGES AND INCONVENIENCIES OF TRANSDERMAL SYSTEMS: Regarding the advantages, one notes the reduction or even suppression of the gastro-intenstinal disorders related to the oral administration of non-steroidal anti-inflammatories ( NSAIDs), the absence of first pass hepatic effect and the better control of the quantities administered of a strong acting drug. Regarding the inconveniencies, one should bear in mind the impossibility of administering or the diffusion of high doses of irritant or sensitizing molecules on the skin. A preparation for application on the skin must be both hydrophilic and lipophilic, with great solubility in water and affinity for the lipids, as is the case with diclofenac epolamine. FROM AN EXPERIMENTAL POINT OF VIEW: Diclofenac epolamine has demonstrated a strong anti-inflammatory effect in the rat or the rabbit, with transfer following repeated local applications, measurable concentrations in the plasma and adjacent tissues, excellent general tolerance and the safety of the plaster. VARIOUS CLINICAL TRIALS: Have shown that the Flector Plaster is well tolerated and effective in the treatment of epicondylitis, sprained ankles, minor sport-induced trauma and osteo- arthrosis of the knee.
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Authors | Marie Solignac |
Journal | Presse medicale (Paris, France : 1983)
(Presse Med)
Vol. 33
Issue 14 Pt 2
Pg. 3S10-3
(Aug 28 2004)
ISSN: 0755-4982 [Print] France |
Vernacular Title | Evaluation d'un anti-inflammatoire non stéroïdien topique dans le traitement de la douleur et de l'inflammation. Exemple de Flector Tissugel 1% dispositif local bioadhésif de diclofénac épolamine. |
PMID | 15509042
(Publication Type: English Abstract, Journal Article, Review)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- diclofenac hydroxyethylpyrrolidine
- Diclofenac
|
Topics |
- Administration, Topical
- Animals
- Ankle Injuries
(complications, drug therapy)
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, therapeutic use)
- Athletic Injuries
(complications, drug therapy)
- Diclofenac
(administration & dosage, analogs & derivatives, pharmacokinetics, therapeutic use)
- Humans
- Inflammation
(drug therapy)
- Osteoarthritis
(complications, drug therapy)
- Pain
(drug therapy)
- Rabbits
- Rats
- Sprains and Strains
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