Abstract |
We report a case of a 58-year-old man with advanced gastric cancer producing sialyl-Tn antigen (STN). Total gastrectomy with distal pancreatectomy and splenectomy was performed. Pathological staging was IV (T 3 N 2 CY1), and most of the cancer cells were strongly positive for anti-STN antibody on immunohistochemical stainings. Serum STN level before the operation was 2,500 U/ml, and the value significantly decreased to the normal range (< 45 U/ml) 2 months after the operation. Low-dose FP (5-FU+CDDP) followed by TS-1 alone (80 mg/day) had been performed as adjuvant chemotherapy. Jaundice appeared and the serum STN level increased again 22 months after the operation. He was diagnosed with a recurrence in the hilar lymph node of the liver. After implantation of expandable stent in the common bile duct, triweekly docetaxel therapy with TS-1 administration (day 1-14) has been performed. Three courses of this therapy have induced a complete response of the recurrent lymph node and the normalization of the serum STN value. No major adverse reaction to this therapy was observed. A complete response and good patient QOL have been achieved during follow-up 8 months after the administration of TS-1 with docetaxel. This case suggests that patients with recurrent gastric cancer who have undergone prior therapy with TS-1 alone could benefit from TS-1 with docetaxel therapy as a second line.
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Authors | Masaya Nomura, Yoshifumi Inoue, Hiroshi Katsura, Shigeo Fujita, Jun Sakao, Hirohiko Yokotani, Shigeo Souda |
Journal | Gan to kagaku ryoho. Cancer & chemotherapy
(Gan To Kagaku Ryoho)
Vol. 31
Issue 10
Pg. 1579-82
(Oct 2004)
ISSN: 0385-0684 [Print] Japan |
PMID | 15508454
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Drug Combinations
- Pyridines
- Taxoids
- S 1 (combination)
- Tegafur
- Docetaxel
- Oxonic Acid
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Chemotherapy, Adjuvant
- Docetaxel
- Drug Administration Schedule
- Drug Combinations
- Drug Resistance, Neoplasm
- Gastrectomy
- Humans
- Lymph Nodes
(pathology)
- Lymphatic Metastasis
- Male
- Middle Aged
- Neoplasm Recurrence, Local
(drug therapy)
- Oxonic Acid
(administration & dosage, pharmacology)
- Pancreatectomy
- Pyridines
(administration & dosage, pharmacology)
- Splenectomy
- Stomach Neoplasms
(drug therapy, pathology, surgery)
- Taxoids
(administration & dosage)
- Tegafur
(administration & dosage, pharmacology)
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