Abstract |
Mithramycin is effective in the treatment of hypercalcemia. The mechanism of its hypocalcemic effect was studied in six patients with hypercalcemia by serum 85Sr or 45Ca kinetic techniques. Mithramycin was given at two dosage levels (25 or 50 microgram/kg iv). Mithramycin at the low dosage had little effect on the rate of bone accretion. However, at both dosage levels, mithramycin caused an upward shift of the slope of the specific activity curve, indicating an inhibitory effect on bone resorption. This effect started 6-12 h after a 25-microgram/kg dose of mithramycin and lasted from 4-6 days. It appears that mithramycin has a preferential effect on bone resorption.
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Authors | D T Kiang, M K Loken, B J Kennedy |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 48
Issue 2
Pg. 341-4
(Feb 1979)
ISSN: 0021-972X [Print] United States |
PMID | 155075
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Phosphates
- Plicamycin
- Calcium
- Strontium
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Topics |
- Calcium
(blood)
- Humans
- Kinetics
- Phosphates
(blood)
- Plicamycin
- Strontium
(blood)
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