Abstract |
Adoptive transfer studies were performed to test the hypothesis that the perforin cytotoxic pathway is more important than the Fas/FasL cytotoxic pathway in protection against experimental murine cytomegalovirus (MCMV) retinitis. Splenic immune cells from donor MCMV-immunized normal mice or gld mice deficient in Fas/FasL-mediated cytotoxicity significantly reduced the frequency and severity of MCMV retinitis following subretinal MCMV challenge when transferred into recipient PKO mice deficient in perforin-mediated cytotoxicity. In sharp contrast, splenic cells from donor MCMV-immunized PKO mice failed to provide protection against MCMV retinitis when transferred into recipient PKO mice. Protection was not achieved, however, in recipient mice with retrovirus-induced immunodeficiency ( MAIDS), even when splenic cells originated from MCMV-immunized normal mice.
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Authors | R D Dix, C O Ekworomadu, E Hernandez, S W Cousins |
Journal | Archives of virology
(Arch Virol)
Vol. 149
Issue 11
Pg. 2235-44
(Nov 2004)
ISSN: 0304-8608 [Print] Austria |
PMID | 15503209
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Membrane Glycoproteins
- Pore Forming Cytotoxic Proteins
- Perforin
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Topics |
- Adoptive Transfer
- Animals
- Cytomegalovirus Retinitis
(prevention & control)
- Cytotoxicity, Immunologic
- Immunization
- Membrane Glycoproteins
(physiology)
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Murine Acquired Immunodeficiency Syndrome
(immunology)
- Muromegalovirus
(immunology)
- Perforin
- Pore Forming Cytotoxic Proteins
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