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A synthetic polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate), stimulates insulin release from RINm5F insulinoma cells.

Abstract
A water-soluble phospholipid-like polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate) (PMC(18), average molecular weight = 4.3 x 10(4)), at a concentration (0.5-5 mg/ml) showing no inhibition of cell proliferation, stimulated insulin release from RINm5F rat insulinoma cells in a concentration- and time-related manner. But poly(2-methacryloyloxyethyl phosphorylcholine) and other synthetic phospholipid-like polymers failed to stimulate insulin release.
AuthorsSusumu Maruyama, Jianen Hu, Akiko Yamanaka, Toshiaki Ichimura
JournalBioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 68 Issue 10 Pg. 2197-200 (Oct 2004) ISSN: 0916-8451 [Print] England
PMID15502370 (Publication Type: Journal Article)
Chemical References
  • Insulin
  • Methacrylates
  • Polymethacrylic Acids
  • poly(2-methacryloyloxyethyl phosphorylcholine-co-n-stearyl methacrylate)
  • poly(2-methacryloyloxyethyl-phosphorylcholine)
  • Phosphorylcholine
Topics
  • Animals
  • Cell Proliferation (drug effects)
  • Exocytosis (drug effects, physiology)
  • Insulin (metabolism)
  • Insulin Secretion
  • Insulinoma (metabolism)
  • Methacrylates (pharmacology)
  • Pancreatic Neoplasms (metabolism)
  • Phosphorylcholine (analogs & derivatives, pharmacology)
  • Polymethacrylic Acids
  • Rats
  • Tumor Cells, Cultured

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