Abstract | OBJECTIVES: STUDY DESIGN: In this randomized, prospective, double-blind, placebo-controlled study, 220 women at 20 to 35 weeks' gestation were evaluated. Subjects received oral erythromycin 333 mg (n = 106) or indistinguishable placebo (n = 114) every 8 hours from randomization to delivery. RESULTS: Prolongation of latency was identified with erythromycin therapy (p = 0.02), particularly for those destined to have chorioamnionitis (p = 0.003) and those with oligohydramnios (p = 0.01). No decrease in the incidence of maternal or neonatal infectious morbidity was seen. CONCLUSIONS: Oral erythromycin delays, but does not prevent, the onset of clinical infection when administered to women with preterm premature rupture of membranes. This regimen does not decrease neonatal morbidity and mortality.
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Authors | B M Mercer, M L Moretti, R R Prevost, B M Sibai |
Journal | American journal of obstetrics and gynecology
(Am J Obstet Gynecol)
Vol. 166
Issue 3
Pg. 794-802
(Mar 1992)
ISSN: 0002-9378 [Print] United States |
PMID | 1550145
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
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Topics |
- Delivery, Obstetric
- Double-Blind Method
- Erythromycin
(therapeutic use)
- Female
- Fetal Membranes, Premature Rupture
(drug therapy)
- Humans
- Infection Control
(methods)
- Pregnancy
- Pregnancy Outcome
- Prospective Studies
- Time Factors
- Vaginal Smears
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