An Indian experiment with nutritional modulation in acute myocardial infarction.

Abstract

In a randomized, single-blind intervention trial, 406 patients 24 to 48 hours after acute myocardial infarction (AMI) were assigned to either diet A (204 patients, group A) or B (202 patients, group B) for 6 weeks. At entry to the study, mean age, male sex, risk factors, complications, possible and definite AMI, and drug therapy were comparable between the 2 groups. Dietary adherence to intervention and control diets was checked by questionnaire, and drug therapy by tablet count. Group A received significantly lower calories, a higher percentage of calories from complex carbohydrates, vegetable/fish proteins, polyunsaturated fatty acids, and a higher polyunsaturated/saturated fat ratio diet than did group B (higher total calories and saturated fatty acids). Group A also received less dietary cholesterol, salt and caffeine, and higher soluble dietary fiber, vitamins and minerals than did group B. After 6 weeks, group A had a significant decrease in mean serum total (-20.5 vs -8.6 mg/dl) and low-density lipoprotein (-16.6 vs -6.4 mg/dl) cholesterols, and triglycerides (-15.5 vs -7.6 mg/dl), with no decrease in high-density lipoprotein cholesterol (-1.5 vs -1.3 mg/dl) compared with the initial levels and changes in group B. Group A also had a greater decrease in mean body weight (3.4 vs 1.3 kg) than that of group B.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: R B Singh, S S Rastogi, R Verma, L Bolaki, R Singh
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 69 Issue 9 Pg. 879-85 (Apr 01 1992) ISSN: 0002-9149 [Print] United States
• PMID: 1550016 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Blood Glucose
• Lipids

Topics

• Adult
• Analysis of Variance
• Blood Glucose (analysis)
• Body Weight
• Humans
• Lipids (blood)
• Middle Aged
• Myocardial Infarction (blood, complications, diet therapy)
• Patient Compliance
• Single-Blind Method